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Nestler EJ (December 2013). "Cellular foundation of memory for addiction". Dialogues in scientific Neuroscience. fifteen (four): 431–443. PMC 3898681. PMID 24459410. In spite of the necessity of a lot of psychosocial variables, at its core, drug addiction includes a Organic system: the power of recurring publicity to the drug of abuse to induce modifications within a susceptible brain that drive the compulsive in search of and taking of medication, and lack of Manage more than drug use, that determine a condition of habit. ... a substantial entire body of literature has shown that these types of ΔFosB induction in D1-type [nucleus accumbens] neurons increases an animal's sensitivity to drug and organic benefits and promotes drug self-administration, presumably through a process of positive reinforcement .

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